Type of Surgery
Last updated: 02/17/2009
Anti-convulsant drug development programs
Once the diagnosis of epilepsy is established, a course of medication is usually prescribed for the control of seizures. ATL only becomes the preferred approach when a patient does not respond...
to medication. As an alternative to surgery, a patient may elect to become an active participant in an anti-convulsant drug development program that may offer an opportunity to participate in studies of experimental medications.
Other surgical techniques
Other surgical techniques such as corpus callosotomy can be performed in selected patients who are ineligible for ATL. In this procedure, the white matter tract connecting the two halves of the brain is cut to halt the spread of seizures and to limit their severity.
Anterior temporal lobectomy is the complete removal of the anterior portion of the temporal lobe of the brain. It is a treatment option in temporal lobe epilepsy for those in whom anticonvulsant medications do not control epileptic seizures.
The techniques for removing temporal lobe tissue vary from resection of large amounts of tissue, including lateral temporal cortex along with medial structures, to more restricted anterior temporal lobectomy (ATL) to more restricted removal of only the medial structures (selective amygdalohippocampectomy, SAH).
Nearly all reports of seizure outcome following these procedures indicate that the best outcome group includes patients with MRI evidence of mesial temporal sclerosis (hippocampal atrophy with increased T-2 signal.) The range of seizure-free outcomes for these patients is reported to be between 80 and 90%, which is typically reported as a sub-set of data within a larger surgical series.
Open surgical procedures such as ATL have inherent risks including damage to the brain (either directly or indirectly by injury to important blood vessels), bleeding (which can require re-operation), blood loss (which can require transfusion), and infection. Furthermore, open procedures require several days of care in the hospital including at least one night in an intensive care unit. Such treatment is quite costly; a factor that may influence some health care systems to avoid referral to qualified centers.
However, a prospective, randomized trial of ATL compared to best medical therapy (anticonvulsants) demonstrated that the seizure-free rate after surgery was ~ 60% as compared to only 8% for the medicine only group. Therefore, ATL is considered the standard of care for patients with medically-intractable mesial temporal lobe epilepsy.
Even patients who had a single metastasis surgically removed should have radiation therapy as there are always individual tumor cells remaining.
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