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Last updated: 11/24/2009
Approximately 30% of people receiving allogeneic transplants do not survive. Autologous transplants have a much better survival rate—nearly 90%—but are not appropriate for all types of ailments requiring a bone marrow transplant. Furthermore, autologous transplants have a higher failure rate with certain diseases, specifically leukemia. At two years, the survival rate for patients with chronic myelogenous leukemia is 52% if they received a transplant in a chronic phase of their disease, 30% for patients in an accelerated phase and 15% for patients in the blast phase.
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This video shows the constant battle between the two main cell types in bone, osteoblasts and osteoclasts. Osteoblasts builds bone while osteoclasts dissolve bone for renovation and remodeling. The video explains how these cells influence the strength of bone throughout life.
Bone marrow consists of red blood cells, white blood cells, and platelets (A). In a bone marrow transplant, bone marrow is harvested from the donor's pelvic bone at the iliac crest (B). The marrow is filtered (C) before being introduced into a large vein in the recipient's chest via a catheter (D). (Illustration by GGS Inc.)
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Bone marrow transplantation involves extracting bone marrow containing normal stem cells from a healthy donor, and transferring it to a recipient whose body cannot manufacture proper quantities of normal blood cells. The goal of the transplant is to rebuild the recipient's blood cells and immune system and hopefully cure the underlying ailment.
From http://www.answers.com/topic/bone-marrow-transplantation
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