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Last updated: 02/17/2009

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New research suggests that a simple blood test may identify people at risk of colorectal cancer. The blood test detects a genetic alteration that may identify people who are likely to develop the disease and who would benefit from additional screening; however, further research has to be done before this test becomes available.

Virtual colonoscopy is a new technique under development and evaluation for screening for colon polyps and cancer, and is undergoing continual improvement. One technique uses images from a magnetic resonance imaging (MRI) scan, and the other uses the x-ray images from a computerized tomography (CT) scan. They both provide views of the colon that are similar to those obtained in a colonoscopy. The images of the colon are produced by computerized manipulations rather than direct observation through the colonoscope.

While the CT scan technique is available in many radiology units, the MRI scan technique is still experimental. The colon is cleaned out using potent laxatives for both types of studies. A virtual image of the colon is formed after the scans are performed, and the images are analyzed and manipulated.

One benefit of the CT scan is that it can find polyps that occasionally are missed by colonoscopy because the polyps lie behind folds within the colon. Nevertheless, criticisms of the CT scan include:

  • It cannot find small polyps (<0.2 in [5 mm] in size) that are easily seen in a colonoscopy.
  • It is less able to find flat polyps compared to a colonoscopy.
  • The procedure does not require patients to be sedated or put under anesthesia, and it can be performed in less than one minute, compared with about 30–60 minutes, plus recovery time required for standard colonoscopy.
  • Small pieces of stool can look like polyps on the CT scan and lead to a diagnosis of polyp when there is none.
  • If colonic polyps are found by virtual colonoscopy, then standard colonoscopy must be done to remove the polyps. As a result, the individual must undergo two procedures.

Although the CT scan is a good option for individuals who cannot or will not undergo standard colonoscopy, it has not been determined if it should be a primary screening tool for individuals at either normal risk or high risk for polyps or cancer.


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Colonoscopy is the endoscopic examination of the large colon and the distal part of the small bowel with a CCD camera or a fiber optic camera on a flexible tube passed through the anus. It may provide a visual diagnosis (e.g. ulceration, polyps) and grants the opportunity for biopsy or removal of suspected lesions. Virtual colonoscopy, which uses 2D and 3D imagery reconstructed from computed tomography (CT) scans or from nuclear magnetic resonance (MR) scans, is also possible, as a totally non-invasive medical test, although it is not standard and still under investigation regarding its diagnostic abilities. Furthermore, virtual colonoscopy does not allow for therapeutic maneuvers such as polyp/tumor removal or biopsy nor visualization of lesions smaller than 5 millimeters. If a growth or polyp is detected using CT colonography, a standard colonoscopy would still need to be performed. Colonoscopy can remove polyps as small as one millimeter or less. Once polyps are removed, they can be studied with the aid of a microscope to determine if they are precancerous or not. Colonoscopy is similar to but not the same as sigmoidoscopy. The difference between colonoscopy and sigmoidoscopy is related to which parts of the colon each can examine. Sigmoidoscopy allows doctors to view only the final two feet of the colon, while colonoscopy allows an examination of the entire colon, which measures four to five feet in length. Often a sigmoidoscopy is used as a screening procedure for a full colonoscopy. In many instances a sigmoidoscopy is performed in conjunction with a fecal occult blood test (FOBT), which can detect the formation of cancerous cells throughout the colon.


From http://en.wikipedia.org/wiki/Colonoscopy

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