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Last updated: 11/24/2009
The USRDS reports that mortality rates for individuals on dialysis are also significantly higher than both kidney transplant patients and the general population, and expected remaining lifetimes of chronic dialysis patients are only one-fourth to one-fifth...
that of the general population. The hospitalization rates for people with ESRD are four times greater than that of the general population.
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This narrated collection of artist's images shows the anatomy of the kidney at the gross and microscopic levels. Kidney physiology is also explained which describes how blood is filtered by the kidney to produce urine.
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In medicine, dialysis (from Greek "dialusis", meaning dissolution, "dia", meaning through, and "lusis", meaning loosening) is primarily used to provide an artificial replacement for lost kidney function (renal replacement therapy) due to renal failure. Dialysis may be used for very sick patients who have suddenly but temporarily, lost their kidney function (acute renal failure) or for quite stable patients who have permanently lost their kidney function (stage 5 chronic kidney disease). When healthy, the kidneys maintain the body's internal equilibrium of water and minerals (sodium, potassium, chloride, calcium, phosphorus, magnesium, sulfate) and the kidneys remove from the blood the daily metabolic load of fixed hydrogen ions. The kidneys also function as a part of the endocrine system producing erythropoietin and 1,25-dihydroxycholecalciferol (calcitriol). Dialysis is an imperfect treatment to replace kidney function because it does not correct the endocrine functions of the kidney. Dialysis treatments replace some of these functions through diffusion (waste removal) and ultrafiltration (fluid removal).
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It's a controversial arena -- the PSA is a marker of prostate bulk and size, but it's highly expressed in benign prostate disease as well as cancer -- so in that context it's not a specific marker.
-Arul Chinnaiyan
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