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Last updated: 02/17/2009
Innovations in islet cell transplants, a procedure that involves transplanting a culture of the insulin-producing islet cells of a healthy pancreas to a patient with type I diabetes, have increased the frequency of this procedure. The Edmonton Protocol,...
a type of islet cell transplant developed in 1999 by Dr. James Shapiro at the University of Alberta (Canada), uses a unique immunosuppresant drug regimen that has dramatically improved success rates of the islet transplant procedure. As of early 2003, the Edmonton Protocol was still considered investigational in the United States, and a number of clinical trials were ongoing.
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A pancreas transplant is an organ transplant that involves implanting a healthy pancreas (one that can produce insulin) into a person who has diabetes. Because the pancreas performs functions necessary in the digestion process, the recipient's native pancreas is left in place, and the donated pancreas attached in a different location. In the event of rejection of the new pancreas, the recipient could not survive without the native pancreas still in place. The healthy pancreas comes from a donor who has just died or it may be a partial pancreas from a living donor. Whole pancreas transplants from living donors are not possible, again because the pancreas is a necessary organ for digestion. At present, pancreas transplants are usually performed in persons with insulin-dependent diabetes who have severe complications.
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