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Last updated: 02/17/2009

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Approximately half of all patients who have received vagal nerve stimulation experience about a 50% reduction in seizures. Another 9% of patients obtain complete relief from seizures. Most patients who continue to take antiseizure medications can reduce...

their dosage, however, which offers some relief from the side effects of these drugs.



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Vagus nerve stimulation (VNS) is an adjunctive treatment for certain types of intractable epilepsy and major depression. VNS uses an implanted stimulator that sends electric impulses to the left vagus nerve in the neck via a lead wire implanted under the skin.

Vagus, the tenth cranial nerve arises from the medulla and carries both afferent and efferent fibers. The afferent vagal fibers connect to the nucleus of the solitary tract which in turn projects connections to other locations in the central nervous system. Little is understood about exactly how vagal nerve stimulation modulates mood and seizure control but proposed mechanisms include alteration of norepinephrine release by projections of solitary tract to the locus coeruleus, elevated levels of inhibitory GABA related to vagal stimulation and inhibition of aberrant cortical activity by reticular system activation


From http://en.wikipedia.org/wiki/Vagus_nerve_stimulation

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Select comparative data from 1999 to 2006 include an 11 percent increase in the number of neurosurgeons with full-time academic appointments and a 6 percent increase in the number of female neurosurgeons.


From: AANS

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